The Spanish Society for Biochemistry and Molecular Biology organizes the 3rd Emerging Scientist Workshop, to be held in Santander (10-13 September 2018).
This Workshop is devoted to those young and promising scientists at the stage of consolidating their careers as independent researchers, between their PhD and a permanent position. It aims to provide a platform from which emerging scientists can show new research lines or recent works and projects with the potential to be incorporated to Research Centers and Institutes.
In prokaryotes, the centromere is a specialized segment of DNA that promotes the assembly of the segrosome upon binding of the Centromere Binding Protein (CBP). Here, we combine biochemical reconstruction and structural and biophysical analysis to bring light to the architecture of the segrosome complex in Type III partition systems.Continue Reading
Combining single-molecule techniques with fluorescence microscopy has attracted much interest because it allows the correlation of mechanical measurements with directly visualized DNA : protein interactions. In particular, its combination with total internal reflection fluorescence microscopy (TIRF) is advantageous because of the high signal-to-noise ratio this technique achieves.Continue Reading
The ParB protein forms DNA bridging interactions around parS to condense DNA and earmark the bacterial chromosome for segregation. The molecular mechanism underlying the formation of these ParB networks is unclear. We show here that while the central DNA binding domain is essential for anchoring at parS, this interaction is not required for DNA condensation.Continue Reading