Alberto Marin-Gonzalez

Alberto Marin-Gonzalez

Phd Student
Bachelor Degree in Physics

Short CV

I obtained a bachelor degree in Physics at the University of Sevilla in 2013 after completing an Erasmus year at the University of Münster. In 2014 I obtained a M.Sc in “Physics and Mathematics” at the University in Granada, where I defended my master thesis on theoretical and computational Higgs physics (“Spin-3/2 top quark excitations and Higgs physics”) supervised by Prof. Dr. Michael Klasen (U. Münster) and Dr. Benjamin Fuchs (CERN). After that I became interested in applying the methods of computational physics to biological/biophysical problems. In this context, in September 2015 I obtained a four year fellowship from the International PhD Program “La Caixa-Severo Ochoa”. Currently I am a PhD student at the Autonomous University of Madrid (UAM) co-supervised by Dr. Fernando Moreno-Herrero (CNB-CSIC) and Prof. Dr. Rubén Pérez (UAM).

Current Project

My project aims at understanding from an atomistic point of view the structure and dynamics of double-stranded nucleic acids. To that end we use atomistic molecular dynamics simulations of nucleic acids in near-to-physiological conditions (explicit water, salt, etc.). Together with Dr. Guilherme Vilhena (currently at the University Basel) we managed to implement a constant force that acts on the molecule during the simulation, thus resembling a magnetic tweezers set-up in-silico. This allowed us to compare the elastic parameters obtained from the simulation with the ones measured from single-molecule experiments. Recently, with the help of Alejandro Martin-Gonzalez, I started working on measuring mechanical properties of DNA molecules using the atomic force microscope to support and extend the results obtained in our simulations.

Research Philosophy

How biological molecules “look like” at the atomic level and how they move (their dynamical response) is key to their function. My research interest consists on bringing together the “microscopic” details provided by the simulations with the “macroscopic” measurements from the experiments with the aim of understanding dynamic biological processes at the nanometer scale.