Carolina Carrasco

Postdoctoral Researcher

ORCID

Degree in Optics and Optometry
Degree in Physics
PhD Doctoral Degree in Sciences

During her Ph.D. period, she extensively used the Atomic Force Microscopy (AFM) to study the mechanical response of single viruses and microtubules upon deformation as well as the dynamics of the kinesin motors under physiological conditions. On 2008, she obtained the Doctoral Degree under the supervision of Dr. P.J. de Pablo with a thesis entitled Structural and mechanical characterization of biological nanosystems with Atomic Force Microscopy. Her Ph.D. work received Cum Laude qualification and it was awarded with the high-level competitive Ph.D. Extraordinary Prize of the Faculty of Sciences of Autónoma University of Madrid.

From 2008 to 2009 she joined as postdoc at ICMM-CSIC, under the supervision of Dr. P.A. Serena, where they explored Frequency Modulation AFM to show true high resolution of viruses at single molecule level in physiological conditions.

In 2009, she moved to CNB-CSIC, under the supervision of Dr. F. Moreno-Herrero, to study recombination DNA break repair by using Magnetic Tweezers (MT) technique. She reported the first use of the MT approach to monitor the dynamics of double-stranded DNA break resection by helicase-nuclease proteins at single molecule resolution. During this period she has been also involved in other collaboration projects where she characterized the elastic response of double-stranded DNA and RNA molecules containing the same sequence under physiological and different salt conditions. From 2009 to 2011 she was supported by a contract of the European Council Research. In June 2011, she was awarded with a high-level competition Juan de la Cierva fellowship.

At present, she is studying the fundamental biological process of Rolling-Circle plasmid Replication involved by PcrA and RepC proteins as well as process of DNA Repair mechanisms. Actually, she enjoys a postdoctoral position financed by a Severo Ochoa Centres of Excellence Grant at the CNB-CSIC.

My Skills

She has a multidisciplinary character since she has been involved in investigating a wide range of phenomena at the physics-biology interface, ranging from the mechanical properties of viruses and microtubules to the dynamics of molecular motors, DNA molecules and DNA-protein interactions using AFM and MT techniques. Following her physics degree, she understood the importance of the application of physical techniques to answer biological questions, and so she has acquired a strong background in Single-Molecule Biophysics. Her research during the last years has been focused on studying the mechanical properties of DNA/RNA molecules and characterizing DNA translocation and unwinding by helicase-nuclease motor proteins.

My Achievments

During her research career, she has collaborated with multidisciplinary and national/international groups providing an output of 21 peer-reviewed papers and 15 conference proceedings. She has published her work in high profile journals such as PNAS, J Struct Biol, Biophysical Journal, JACS, PLoS One, NAR, Small, DNA Repair. The total number of citations is over 650, and the h-index is 14, with an average of citations per article of 23.29. The average impact of the journals where she published her research is 5.616. She has participated as speaker in high-up international congresses such as Gordon Research Conferences, European Biophysics Congress and Biophysical Society Meeting and has contributed to 68 conferences, 29 oral presentations and 28 posters, and 8 invited talks to diverse research institutions in Germany, U.S.A and Spain.