We are interested in studying dsDNA break repair and Chromosome organisation at the single molecule level using Atomic Force Microscopy, Magnetic Tweezers, Fluorescence, and standard biochemical techniques.
Welcome to the Moreno-Herrero Lab
The main interest of my group is to answer key questions in DNA-break repair, replication and Chromosome organisation using novel approaches based on single-molecule techniques. To do this, we develop our own instrumentation based on Atomic Force Microscopy imaging, single-molecule manipulation techniques such as Magnetic Tweezers combined with fluorescence, and establish strategic collaborations with research groups specialized on different biological systems. We are also interested in studying the mechanical properties of nucleic acids and their role in protein interaction. We investigate this from an experimental perspective using our single-molecule tools but also by all-atom molecular dynamics simulations.
We work at the National Center of Biotechnology (CNB), a research center part of the Spanish National Research Council (CSIC). The CNB is the largest CSIC institute with over 600 people working in a multidisciplinary environment that combines the latest technology in molecular biology, and structural and functional biology.
Check out our Openings section for opportunities to join the group to do the Master project, PhD or Postdoctoral research.
Research lines
NEWS & EVENTS
Bacillus subtilis MutS modulates RecA-mediated DNA strand exchange between divergent DNA sequences
DNA crookedness regulates DNA mechanical properties at short length scales
Human CtIP forms a tetrameric dumbbell-shaped particle which binds and bridges complex DNA end structures for double-strand break repair
