The 2025 meeting will provide a forum for the rapidly growing field of helicase-related research, a phenomenon fueled by the fact that helicase defects are associated with a broad spectrum of disorders characterized by premature aging, susceptibility to cancers and other diseases normally associated with aging, immunodeficiency or developmental abnormalities (including Bloom syndrome, Werner syndrome, Fanconi Anemia, Xeroderma pigmentosum, Cockayne syndrome, trichothiodystrophy and hereditary forms of breast cancer).